Clinical significance and expression of the PRSS3 and Wiskott–Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer

Azizmohammadi, Sima and Safari, Aghdas and Seifoleslami, Mehri and Ghaffarzadegan Rabati4, Rahman and Mohammadi, Mohsen and Yahaghi, Hamid and Azizmohammadi, Susan (2017) Clinical significance and expression of the PRSS3 and Wiskott–Aldrich syndrome protein family verprolin-homologous protein 1 for the early detection of epithelial ovarian cancer. International Society of Oncology and BioMarkers.

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Abstract

In this study, we evaluate the clinical significance of the PRSS3 and Wiskott–Aldrich syndrome protein family verprolin-homologous protein 1 (WAVE1) in patients with epithelial ovarian cancer (EOC) by immunohistochemistry. In current study, all adjacent non-cancerous tissues showed absent or low expression of PRSS3. The expression of PRSS3 was significantly increased in the EOCs than adjacent noncancerous tissues. Moreover, the expression of WAVE1 was significantly observed in all EOC tissues when compared with normal tissues. Furthermore, WAVE1 expression was absent in 35 (89.74 %) adjacent non-cancerous tissues. Our findings showed that high expression of PRSS3 was markedly linked to FIGO stage (P=0.02), advanced grade (P=0.017), and lymph node metastases (P=0.001), but no relationship was determined with other clinicopathological parameters. Furthermore, high expression of WAVE1 was significantly correlated with FIGO stage (P=0.001), grade of tumor (P=0.011), and residual tumor size (P=0.041), but no significant associations were found between WAVE1 expression and age, lymph node metastasis, and histological subtypes (all P>0.05). In conclusion, our study showed that increased expression of PRSS3 andWAVE1 may be involved in development of EOC.

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