Moradi Vahdat, Maryam and Rezaei, Nahid and Ghorbani, Abozar and Eskandari, Mohammad Hadi and Niazi, Ali (2021) Hepatitis B core-based virus-like particles: A platform for vaccine development in plants. Biotechnology Reports.
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Abstract
Virus-like particles (VLPs) are a class of structures formed by the self-assembly of viral capsid protein subunits and contain no infective viral genetic material. The Hepatitis B core (HBc) antigen is capable of assembling into VLPs that can elicit strong immune responses and has been licensed as a commercial vaccine against Hepatitis B. The HBc VLPs have also been employed as a platform for the presentation of foreign epitopes to the immune system and have been used to develop vaccines against, for example, influenza A and Foot-and-mouth disease. Plant expression systems are rapid, scalable and safe, and are capable of providing correct post-translational modifications and reducing upstream production costs. The production of HBc-based virus-like particles in plants would thus greatly increase the efficiency of vaccine production. This review investigates the application of plant-based HBc VLP as a platform for vaccine production.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 05 Apr 2021 05:11 |
| Last Modified: | 05 Apr 2021 05:11 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2688 |
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