The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats

Moghaddasi, Mehrnoush and Taati, Majid and Asadian, Payman and Khalatbary, Ali Reza and Asaei, Raheleh and Pajouhi, Naser (2016) The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats. J Physiol Sci.

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Abstract

Abstract The purpose of this study was to evaluate the effects of cerebral hypoperfusion on cognitive ability, TNFa, IL1b and PGE2 levels in both hippocampi in a modified two-vessel occlusion model. Both common carotid arteries of adult male Wistar rats were permanently occluded with an interval of 1 week between occlusions. Learning and memory were significantly decreased after 1 month. This reduction was not significant after 2 months, which may be attributed to blood flow compensation. The TNFa level was significantly increased after 3 h and 1 day. IL1b was significantly increased after 1 day. After a week there was no significant difference in pro-inflammatory levels. Furthermore, there was no difference between right and left hippocampi. It is possible that TNFa and IL1b elevation initiates pathologic processes that contribute to memory impairment.

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