The Antioxidant and Antiangiogenic Effects of Dietary supplement of Nigella sativa Crude Oil on Breast Tumor in BALB/c Mice

Bigdeli, Mohammad Reza and Bahramian, Sima Bahramian and Rasoulian, Bahram (2016) The Antioxidant and Antiangiogenic Effects of Dietary supplement of Nigella sativa Crude Oil on Breast Tumor in BALB/c Mice. Herbal Medicines Journal, 1 (1). pp. 1-10. ISSN 2538-2144

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Abstract

Background and Aim: Cancer embraces a vast range of diseases including that of the breast and is trigger by various factors such as reactive species of oxygen. Angiogenesis, then, aids the cancerous mass to meet needs and develop further. Nigella sativa L. (NS), traditionally cultivated and consumed in the Middle East, h long been appreciated for its medicinal benefits. In this study, we aimed to look into its antioxidant and an angiogenic effects on breast tumor in BALB/c mice. Materials and Methods: 3 groups of BALB/c mice, respectively received 1, 2 and 4 ml/kg/day of NS crude o via gavaging for 4 months before breast tumor transplantation, while the control mice were gavaged wi distilled water. Then tumor volume, the activity of antioxidant enzymes, the amounts of VEGF and endostat were studied to examine NS crude oil’s impact against breast tumor. Results and Conclusions: Our findings revealed that the mice pretreated with 4 ml/kg/day of NS oil h significantly smaller tumor volumes, higher SOD and CAT activity, reduced VEGF and increased endostat amounts. So, we came to this that Nigella sativa crude oil seems to inhibit breast tumor growth in part b improving the activity of antioxidant enzymes and in part by interfering with angiogenesis. More studies ar yet, required to better illuminate its other mechanisms of involvement. Keywords: Breast cancer, Antioxidants, Nigella sativa L., Superoxide dismutase, Catalase, Angiogenesi Endostatin

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