Golbaghi, Navid and Naeimi, Saeideh and Darvishi, Afra and Najari, Niloofar and Cussotto, Sofia (2024) Probiotics in autism spectrum disorder: Recent insights from animal models. Autism : the international journal of research and practice.
Full text not available from this repository.Abstract
Autism spectrum disorder is a neurodevelopmental disorder characterized by a wide range of behavioral alterations, including impaired social interaction and repetitive behaviors. Numerous pharmacological interventions have been developed for autism spectrum disorder, often proving ineffective and accompanied by a multitude of side effects. The gut microbiota is the reservoir of bacteria inhabiting our gastrointestinal tract. The gut microbial alterations observed in individuals with autism spectrum disorder, including elevated levels of Bacteroidetes, Firmicutes, and Proteobacteria, as well as reduced levels of Bifidobacterium, provide a basis for further investigation into the role of the gut microbiota in autism spectrum disorder. Recent preclinical studies have shown favorable outcomes with probiotic therapy, including improvements in oxidative stress, anti-inflammatory effects, regulation of neurotransmitters, and restoration of microbial balance. The aim of this review is to explore the potential of probiotics for the management and treatment of autism spectrum disorder, by investigating insights from recent studies in animals. Keywords: Autism Spectrum Disorder; Lactobacillus; animal models; gut-brain axis; probiotics.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 12 May 2024 06:45 |
| Last Modified: | 12 May 2024 06:45 |
| URI: | http://eprints.lums.ac.ir/id/eprint/4765 |
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