Shahzamani, Kiana and Esmaeil Lashgarian, Hamed and Karkhane, Maryam and Ghaffarizadeh, Azin and suresh, Ghotekar and Marzban, Abdolrazagh (2022) Bioactivity assessments of phyco-assisted synthesized selenium nanoparticles by aqueous extract of green seaweed, Ulva fasciata. Emergent Materials.
Full text not available from this repository.Abstract
Currently, diverse forms of selenium featuring extensive bioactivities have drawn much attention as nutrients for the body’s normal functioning. The synthesis of cost-effective and eco-friendly selenium nanoparticles (SeNPs) was accomplished using aqueous extract of Ulva fasciata (UF extract) as reducing and capping agents. SEM and TEM imaging, FTIR and UV–visible spectroscopy, XRD and EDX analysis, and DLS and zeta potential measurements were used to characterize the physicochemical properties of UF-SeNPs. The biological activity of UF-SeNPs was evaluated on MDA-MB-231, including cytotoxicity, apoptosis, and necrotic induction. UF-SeNPs were also examined for antibacterial efficacy against gram-positive and negative pathogens. Based on SEM, TEM, and XRD analyses, UF-SeNPs were found to get an amorphous structure size of 20–50 nm. Combining UF-SeNPs with chloramphenicol (10 µg/ml) demonstrated synergistic effects against S. aureus and P. aeruginosa with MIC values of 125 and 250 µg/ml, respectively. UF-SeNPs exhibited the highest caspase-3/7 activity at doses around the IC50 (11 µg/ml), and the matrix metalloproteinase-2 and 9 (MMP-2 and 9) were severely inhibited and lactate dehydrogenase leakage was enhanced. Our findings indicate that UF extract can be useful as a source of nanoparticles with interesting biological properties, especially as an effective anticancer agent.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RV Botanic, Thomsonian, and eclectic medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 05 Nov 2022 04:59 |
| Last Modified: | 05 Nov 2022 04:59 |
| URI: | http://eprints.lums.ac.ir/id/eprint/3969 |
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