The effect of chitosan nanogel and essential oil of peppermint (Menthapiperita) on clinical isolates of Acinetobacter baumannii in-vitro

Delfani, Somayeh and Rashidipour, Marzieh and Rezaei, Faranak and Shakib*, Pegah (2022) The effect of chitosan nanogel and essential oil of peppermint (Menthapiperita) on clinical isolates of Acinetobacter baumannii in-vitro. Yafteh, 23 (5).

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Abstract

Background: One of the most important problems of health care systems is the increasing prevalence of antibiotic-resistant bacterial infections. Today, the use of natural substances such as plant essential oils with antimicrobial properties as an alternative to antibiotics is increasing. The aim of this study was to evaluate the effect of chitosan nanogels containing essential oil of peppermint (Menthapiperita) on clinical isolates of Acinetobacter baumannii in in vitro. Materials and Methods: In this cross-sectional study, Acinetobacter baumannii were isolated from selected hospitals in Khorramabad. After preparing nanogels containing peppermint essential oil (Menthapiperita), the minimum inhibitory concentration (MIC) of chitosan nanogels on Acinetobacter baumannii isolates was determined by micro broth dilution method in plate 96 wells according to CLSI instructions. Results: The mean minimum inhibitory concentrations (MIC) of nanoparticles without essential oil of peppermint, nanoparticles containing peppermint and gentamicin were 47±496, 48±301, and 25±25, respectively. Indications of high sensitivity of the studied strains to gentamicin in comparison with the other two groups (P≤0.001) and more effective performance of Menthapiperita in MIC of Acinetobacter baumannii strains compared to nanoparticles without peppermint essential oil (P≤0.001). Conclusion: The results of the present study indicate the effective ability of chitosan nanogels containing peppermint essential oil in comparison with non-essential nanoparticles (Menthapiperita) to inhibit the growth of Acinetobacter baumannii isolates. Keywords: Nanogel, Essential oil of Mentha piperita, Acinetobacter baumannii, Chitosan

Item Type: Article
Subjects: R Medicine > RA Public aspects of medicine
Depositing User: mania jalilvand
Date Deposited: 09 Mar 2022 08:32
Last Modified: 09 Mar 2022 08:32
URI: http://eprints.lums.ac.ir/id/eprint/3692

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