Asbaghi, Omid and Nazarian, Behzad and Rezaei kelishadi, Mahnaz and Naeini, Fatemeh and Moradi, Sajjad Lycopene Supplementation and Blood Pressure: Systematic review and meta-analyses of randomized trials. Journal of Herbal Medicine.
Full text not available from this repository.Abstract
Background & aims Hypertension is a predisposing factor for cardiovascular disease (CVD). Results of previous clinical trials on the effects of lycopene supplementation on blood pressure are inconsistent. This systematic review and meta-analysis of randomized trials with parallel or cross-over design was conducted to summarize the effects of lycopene supplementation on blood pressure (BP). Methods A systematic search was carried out in PubMed, SCOPUS, EMBASE and ISI Web of Science, without any restrictions on date and language publication to February 2020. Data were pooled using random-effects method and were expressed as weighted mean difference (WMD) and 95% confidence intervals (CI). Results The elementary search consisted of 2564 records. Finally, 10 RCTs were included in the study. The pooled results of 10 studies with 16 effect size sizes including 688 participants (case=438 and control=250) showed that lycopene supplementation significantly decreased systolic blood pressure (SBP) (weighted mean differences (WMD): − 2.63 mmHg; 95% CI: − 5.17, − 0.09; P = 0.042). Greater effects on SBP were observed in subjects with a baseline SBP≥ 130 mmHg, at the lycopene dosages of ≥ 15 mg, duration≥ 8 weeks, and in hypertensive subjects. The changes observed in diastolic blood pressure (DBP) (WMD: −1.02 mmHg; 95% CI: −2.51, 0.46; P = 0.179) were not statistically significant. However, subgroup analysis showed that DBP decreased significantly in studies that enrolled hypertensive subjects or with elevated DBP (>80 mmHg). Lycopene supplementation reduced SBP in non-linear fashion based on dosage (P-nonlinearity = 0.04, Coef = −9.68). Conclusion The present study demonstrates the beneficial effects of lycopene supplementation on BP levels.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 26 Nov 2021 05:24 |
| Last Modified: | 26 Nov 2021 05:24 |
| URI: | http://eprints.lums.ac.ir/id/eprint/3343 |
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