Nemati, Afsaneh and Beyranvand, Fatemeh and Assadollahi, Vahideh and Salahshoor, Mohammad Reza and Alasvand, Masoud (2020) The effect of different concentrations of cerium oxide during pregnancy on ovarian follicle development in neonatal mice. Birth Defects Res.
Full text not available from this repository.Abstract
Objectives: Cerium is a member of the rare metals group and widely used in drug delivery, gene therapy, molecular imaging and medicine. In this study, we investigated the effect of different doses of Cerium (IV) oxide (CeO2 ) during pregnancy on neonatal mice ovaries, as well as its effect on blood biochemical parameters. Methods: Thirty pregnant NMRI mice were divided into five groups: Control and 4 groups treated with CeO2 (10, 25, 80, 250 mg/kg.bw i.p) at the GD7 and GD14. The ovarian histological of neonatal (2 and 6 day-olds), as well as blood serum of neonates at 15-dpp were analyzed. Results: Count of ovarian primordial follicles in neonates at 2 dpp showed a significant decrease in the groups treated with 80 and 250 mg/kg.bw doses of CeO2 . There was also a significant decrease in ovarian pri
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 15 Sep 2021 04:38 |
| Last Modified: | 15 Sep 2021 04:38 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2989 |
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