Ghalishourani, Samira Sadat and Asbaghi, Omid and Ghaedi, Ehsan and Behrouzian, Mahsa and Khadem Haghighian, Hossein and Moodi, Vihan (2021) Effects of grape products on inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials. phytotrapy research.
Full text not available from this repository.Abstract
This systematic review and meta‐analysis of randomized controlled trials (RCTs) were conducted to determine the effects of grapes and grape products on inflammation and oxidative stress among adults. PubMed, Scopus, ISI Web of Science, and Cochrane Library databases were searched up to July 2020 to identify RCTs investigating the effects of grape and grape products on inflammatory and oxidative stress markers. Weighted mean differences (WMD) were pooled using a random‐effects model. Of the 8,962 identified studies, 24 RCTs (27 arms) were included in the statistical analysis. Grape products significantly reduced serum C‐reactive protein (CRP) levels (WMD: −0.35 mg/L; 95% CI: −0.62, −0.09, p = .008), but they had no significant effect on serum tumor necrosis factor‐alpha (TNF‐α) (WMD = −1.08 pg/ml; 95% CI: −2.29, 0.11, p = .07), interleukin‐6 (IL‐6) (WMD = 0.13 pg/ml; 95% CI: −0.35, 0.60, p = .60), total antioxidant capacity (TAC) (WMD = 0.15; 95% CI: −0.35, 0.65, p = .54), or malondialdehyde (MDA) (WMD = 0.14; 95% CI: −0.64, 0.92, p = .72). The analysis indicated possible decreasing effects of grapes and grape products on CRP, but they might not be able to change IL‐6, TNF‐α, TAC, and MDA concentrations. Nonetheless, further studies are warranted before definitive conclusions may be reached.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 01 May 2021 05:44 |
| Last Modified: | 01 May 2021 05:44 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2737 |
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