Delfani, Somayeh and Kalantar-Neyestanaki, Davood and Goudarzi, Gholamreza and Soroush, Setareh and Rezaei *, Faranak (2020) Characterization co-existence of ESBLs, AmpC and MBLs in Escherichia coli and Klebsiella pneumoniae isolates from Khorramabad Hospitals. Yafteh, 22 (3).
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Abstract
Background: Prevalence of co-existence of extended-spectrum β-lactamases (ESBLs), metallo-beta-lactamase (MBLs) and AmpC-β-lactamases producing isolates in these bacteria is a serious problem in treatment of infections. The aim of this study was to characterization co-existence of ESBLs, AmpC and MBLs in Escherichia coli and Klebsiella pneumoniae isolates from Khorramabad hospitals. Materials and Methods: In this descriptive cross-sectional study, totally 130 clinical isolates including E. coli (n=45) and K. pneumoniae (n=85) were collected from hospitals of Khorramabad. Disk diffusion method used for determination of susceptibility of isolates to antibiotics. ESBLs, MBLs and AmpC-β-lactamases producing isolates detected by combined disk methods. Polymerase chain reaction (PCR) was used to detection of blaTEM, blaSHV and blaVIM genes. Results: Out of the 130 clinical isolates, 41(31.5%) and 37 (28.4%) of them considered as ESBLs and AmpC producing, respectively. The blaTEM and blaSHV detected in 24 (18.4%) and 23 (17.6%) of isolates, respectively. Conclusion: Prevalence of ESBLs, AmpC and MBLs in Khorramabad is lower than from other regions of Iran. Outbreak of co-producer ESBLs, AmpC and MBLs isolates in Khorramabad can cause serious problems in treatment of infections. Keywords: Klebsiella pneumoniae, Escherichia coli, β-lactamases
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Depositing User: | mania jalilvand |
| Date Deposited: | 08 Feb 2021 05:43 |
| Last Modified: | 08 Feb 2021 05:43 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2615 |
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