The Relationship between Serum Vitamin C and Uric Acid Levels, Antioxidant Status and Coronary Artery Disease: a Case-Control Study

Torkzaban, Aida and Alavi Naeini, Amirmansour and Namdari, Mehrdad and Hassanzadeh, Akbar (2020) The Relationship between Serum Vitamin C and Uric Acid Levels, Antioxidant Status and Coronary Artery Disease: a Case-Control Study. CLINICAL NUTRITION RESEARCH.

Preview

Text injaaaaa.pdf Download (835kB) | Preview

Abstract

Coronary artery disease (CAD) is among the main causes of death in adults. Increase of oxidative stress and defects in antioxidant defense play a major role in endothelium performance and are affecting factors in the progress of atherosclerosis. The aim of this study was to measure serum levels of uric acid (UA) and vitamin C as well as the antioxidant status in patients with CAD, and compared them with those in healthy individuals. The present case-control study was performed on 44 cases and 44 controls. Demographic data and anthropometric indices were measured. The Food Frequency Questionnaire (FFQ) and International Physical Activity Questionnaire (IPAQ) were completed. Afer 12 hours of fasting,10 mL blood was sampled from the participants. Serum levels of UA, vitamin C, Total Antioxidant Capacity (TAC) and Malondialdehyde (MDA) were also measured. The data were fnally analyzed by SPSS v22. A signifcant difference was observed between the groups in terms of UA and vitamin C. However, mean levels of MDA and TAC were not signifcantly different between groups. The differences between groups in terms of vitamin A, vitamin E, beta-carotene, zinc and selenium intakes were not signifcant either. A signifcant difference was detected between the groups in terms of vitamin C intake. Our results suggest that increase in UA and decrease in vitamin C in serum levels can be considered as risk factors for CAD patients. Due to a lack of any signifcant correlation between TAC and CAD risk in this study, further study with bigger sample size is needed. Keywords: Ascorbic acid; Uric acid; Atherosclerosis; Coronary artery disease

Actions (login required)

View Item