In vitro potential effect of Pipper longum methanolic ‎extract against protoscolices of hydatid cysts

Cheraghipour‎, Kourosh and Beiranvand‎, Marjan and Zivdari‎, Masoomeh and Amiri‎, Sana and Masoori ‎, Leila and Abbaszadeh‎, Saber and Moradpour‎, Kobra and Marzban, Abdolrazagh (2020) In vitro potential effect of Pipper longum methanolic ‎extract against protoscolices of hydatid cysts. Experimental Parasitology.

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Abstract

This study aimed to evaluate the efficacy of methanolic extract of P. ‎longum (PLM) against protoscolices of hydatid cyst in vitro. Four different ‎concentrations of PLM extract (25, 50, 100 and 150 mg/ml) were used for the ‎experiments. The metabolites in the PLM extract were characterized by Gas ‎chromatography-mass spectrometry (GC-MS). The results showed the highest ‎lethality of PLM extract in 50 mg/ml for 60 min exposure. The IC50 value ‎obtained about 20 mg/ml for 60 min of PLM extract exposure. In this study, ‎valuable findings were obtained for the first time about the scolicidal activity ‎of P. longum, which is expected to conduct further studies in this field in the ‎future.‎

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 16 Dec 2020 07:47
Last Modified: 16 Dec 2020 07:47
URI: http://eprints.lums.ac.ir/id/eprint/2480

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