Nemati, Afsaneh and Beyranvand, Fatemeh and Assadollahi, Vahideh and Salahshoor, Mohammad Reza (2020) The effect of different concentrations of cerium oxide during pregnancy on ovarian follicle development in neonatal mice. Birth Defects Research.
Full text not available from this repository.Abstract
Objectives Cerium is a member of the rare metals group and widely used in drug delivery, gene therapy, molecular imaging and medicine. In this study, we investigated the effect of different doses of Cerium (IV) oxide (CeO2) during pregnancy on neonatal mice ovaries, as well as its effect on blood biochemical parameters. Methods Thirty pregnant NMRI mice were divided into five groups: Control and 4 groups treated with CeO2 (10, 25, 80, 250 mg/kg.bw i.p) at the GD7 and GD14. The ovarian histological of neonatal (2 and 6 day‐olds), as well as blood serum of neonates at 15‐dpp were analyzed. Results Count of ovarian primordial follicles in neonates at 2 dpp showed a significant decrease in the groups treated with 80 and 250 mg/kg.bw doses of CeO2. There was also a significant decrease in ovarian primordial and primary follicles in neonates at 6‐dpp at 250 mg/kg.bw doses of CeO2 in the control (P < 0.05). There was no significant difference in serum levels of malondialdehyde and total antioxidant capacity between the experimental and control groups. Conclusions Our results suggest that the effects of CeO2 on the ovarian tissue of neonatal mice during pregnancy may be dose‐dependent.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 16 Dec 2020 07:00 |
| Last Modified: | 16 Dec 2020 07:00 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2472 |
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