Shahsavar, Farhad and Mousavi, Nazanin and Ahmadi, Seyyed Amir Yasin and Nekouian, Reza (2020) Association of FOXP3 polymorphisms with susceptibility to multiple sclerosis: a meta-analysis on genetic association studies. • Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics).
Full text not available from this repository.Abstract
Objectives FOXP3 is a gene related to regulatory T cells existing on chromosome X. This meta-analysis on genetic association studies is conducted to investigate association of FOXP3 polymorphisms with susceptibility to multiple sclerosis (MS). Methods All genetic association studies covering both FOXP3 and multiple sclerosis terms were searched in PubMed, Web of Science and Google Scholar. The information of genotype frequencies were summarized and synthesis of the results was through odds ratio (OR). Heterogeneity and publication bias were investigated using I2 scale and Begg's funnel plot respectively. Results For rs3761546 -3279 C/A polymorphism, AA/AY genotypes was a risk factor in comparison to CC/CY genotypes (P =0.022; OR =1.752; 95% confidence interval [CI] =1.084-2.830; random). AC genotype was a risk factor in comparison to CC/CY genotypes (P =0.004; OR =1.537; 95% CI =1.145-2.062; random) and in comparison to homozygote genotypes (P =0.016; OR =1.216; 95% CI =1.038-1.426; fixed). For rs2232365 -924 G/A polymorphism, 2 significant associations were found according to fixed effect model; of course they were not remained significant in random effect model. Conclusion According to the collected populations, susceptibility to and protection from MS is associated with rs3761546 -3279 C/A upstream polymorphism. However it should be regarded that this association is ethnicity dependent.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 07 Oct 2020 04:16 |
| Last Modified: | 07 Oct 2020 04:16 |
| URI: | http://eprints.lums.ac.ir/id/eprint/2396 |
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