Maleki, Abbas and Ghafourian, Sobhan and Soroush, Setareh and Taherikalani, Morovat (2018) Alarming and Threatening Signals from Health Centers About Multi Drug Resistance Staphylococcus haemolyticus. Infectious Disorders - Drug Targets.
Full text not available from this repository.Abstract
Objectives: Nowadays, due to the biofilm formation among coagulase-negative staphylococci (CoNS), acquisition of antibiotic resistance and virulence genes could be noted. These organisms resemble other staphylococcus that harbor mecA gene, which encodes methicillin resistance but the diversity in CoNS is higher than other species. Based on increasing antibiotic resistance in Staphylococcus haemolyticus, analyzing of phenotypic and genotypic biofilm formation, antibiotic resistance and genes involved in this process, SCCmec and ACME typing were the aims of the current study. Methods: 256 clinical CoNS isolates were collected, out of which 49 isolates were identified as S. haemolyticus. For evaluation the antibiotic resistance patterns, disk agar diffusion method was applied, and also biofilm assay was carried out among methicillin resistant S. haemolyticus and SCCmec and ACME typing. Results: The results of antibiotic susceptibility indicated that the highest resistance was found in cotrimoxazole and erythromycin (86.6%) and the frequency of blaA (96.5%) and msrA (79.3%) genes was much higher than others. Among MRSH isolates 58.6 % showed a weak biofilm phenotype and 41.4% demonstrated a moderate biofilm density. Also, among the biofilm correlated genes, IS 256 (79.31%) was the most frequent. The SCCmec typing of MRSH isolates indicated that the type V was dominant. Conclusion: Our findings indicated that the correlation between high rates of existence Is 256 gene and high prevalence of weak biofilm phenotype was among MRSH isolates. The current study revealed that multiple antibiotic resistance existed in S. haemolyticus isolates that is a warning for public health.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 06 Nov 2018 07:13 |
| Last Modified: | 06 Nov 2018 07:13 |
| URI: | http://eprints.lums.ac.ir/id/eprint/1448 |
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