Chemical composition, protoscolicidal effects and acute toxicity of Pistacia atlantica Desf. fruit extract

Mahmoudvand, Hossein and Kheirandish, Farnaz and Ghasemi Kia, Mehdi and Tavakoli Kareshk, Amir and Yarahmadi, Mohammad (2016) Chemical composition, protoscolicidal effects and acute toxicity of Pistacia atlantica Desf. fruit extract. NATURAL PRODUCT RESEARCH.

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Abstract

The present study was designed to evaluate the chemical composition and scolicidal effects of Pistacia atlantica Desf. extract against protoscoleces of hydatid cysts and its acute toxicity in mice model. Various concentrations of the methanolic extract (5–50 mg/mL) were used for 10–60 min. Viability of protoscoleces was confirmed using eosin exclusion test (0.1%). Acute toxicity was also determined in mice model. The main components were β-myrcene (41.4%), α-pinene (32.48%) and limonene (4.66%). Findings demonstrated that P. atlantica extract at the concentrations of 25 and 50 mg/mL after 20 and 10 min of exposure killed 100% protoscoleces. The LD50 of the intraperitoneal injection of the P. atlantica methanolic extract was 2.43 g/kg and the maximum non-fatal dose was 1.66 g/kg. Obtained results showed the potential of P. atlantica extract as a natural source with no significant toxicity for the production of new scolicidal agent to use in hydatid cyst surgery.

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