Evaluation and comparison of endurance training with fluoxetine supplementation 4 weeks on depression and heart 1β adrenergic receptors in male Wistar rats

Kohneshin*, Bezad and Piree, Mghsod and Matinhomaee, Hasan (2017) Evaluation and comparison of endurance training with fluoxetine supplementation 4 weeks on depression and heart 1β adrenergic receptors in male Wistar rats. Yafte, 19 (2).

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Abstract

Background : Long-term exposure to anxiety and depression puts myocardium at risk of failure. Neurohormone Message caused be depression delivered to the heart by beta1 adrenoreceptor. The aim of this study was to survey and compare the effect of 4 weeks of endurance training with fluoxetine treatment on beta-adrenergic receptors in the male Wistar rat heart. Materials and Methods: This research method is experimental. In this study, 24 male Wistar rats divided randomly into three groups. To each of the rats, exercise and supplementation group, fluoxetine 0.8 mg /kg of body weight LPS injected Intraperitoneal. Exercise group run for the 4-week on the treadmill at a speed of 20 meters per minute for 45 minutes each day. Fluoxetine group received 0.5 mg of oral fluoxetine. To prove the effects of LPS injection per and post FST test results analyzed using T-test for dependent samples. Pre and post-test FST data for each group using T-test at a significance level( α <0.05), and cardiac receiver data were analyzed by one-way ANOVA. Results: The mean density of beta-1 adrenergic receptors in the training group were significantly lower than the depressed group (P <0.05). The mean density of beta-1 adrenergic receptors in the training group were not significant in comparison to the fluoxetine group. Conclusion: Endurance training can prevent a significant increase in the density of adrenergic beta-1 receptors in the heart of the depressed rats. Keywords: Intense Endurance Exercise, Beta-1 Adrenergic Receptor, FST Test.

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