Cardioprotective effects of exercise and curcumin supplementation against myocardial ischemia–reperfusion injury

Sayevand, Zahra and Nazem, Farzad and Nazari, Afshin and Sheykhlouvand, Mohsen (2022) Cardioprotective effects of exercise and curcumin supplementation against myocardial ischemia–reperfusion injury. Sport Sciences for Health.

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Purpose Myocardial injury induced by ischemia–reperfusion is the main pathological contributing factor of cardiovascular disease (CVD) including heart failure. Individually, both moderate-intensity aerobic exercise and curcumin supplementation have anti-amyloidogenic effects, however, the concurrent effects are unclear. We, therefore, investigated the effects of 10 weeks of moderate-intensity aerobic exercise with and without curcumin supplementation in rats. Methods Male Wistar rats (6–8 weeks old) were randomly assigned to one of five groups (N = 10): (a) sedentary control; (b) sedentary ischemia–reperfusion; (c) exercise (15–45 min at 12–24 m/min) with ischemia–reperfusion; (d) curcumin (50 mg/kg/day) + ischemia–reperfusion; and (e) both exercise and curcumin + ischemia–reperfusion. Infarct size, gene expression of amyloid precursor protein, enzymes involved in the cleavage of amyloid precursor protein (β-secretase-1, presenilin-1 and -2) and neprilysin, a marker of degradation of β-amyloid peptide in the left ventricle of rats were investigated. Results A reduction in mRNA expression of amyloid precursor protein, β-secretase-1, presenilin-1 and -2 and infarct size, and an increase in gene expression of neprilysin in the myocardium occurred in both the exercise- and the curcumin-treated rats with no further benefit with concurrent treatments. Conclusion Exercise and curcumin individually provided cardioprotective effects against ischemia–reperfusion-induced injury which appears to be associated with an attenuation in mRNA expression of β-amyloid peptide precursor in addition to processing enzymes and an increase in mRNA expression of neprilysin. There were no further benefits with concurrent treatments (exercise with curcumin) compared to either treatment alone.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 12 Mar 2022 10:04
Last Modified: 12 Mar 2022 10:04

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