Effect of different exercises on effective factors involved in reverse cholesterol transfer in patients with coronary artery bypass surgery

Shorideh, Ziba and Ravasi, Ali Asghar and Nouri*, Reza and Rashidlamir, Amir (2021) Effect of different exercises on effective factors involved in reverse cholesterol transfer in patients with coronary artery bypass surgery. Yafteh, 23 (4).

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Abstract

Background: The present study aimed to compare the effect of different exercises on effective factors involved in reverse cholesterol transfer in patients with coronary artery bypass surgery (CABG). Materials and Methods: A number of 45 patients with CABGwere assigned to three groups: control (n=12), aerobic exercise (n=15), and resistance training (n=18). Three aerobic and resistance training sessions were performed per week for eight weeks. Anthropometric variables, expression of ABCG4 gen, as well as the serum levels of Apo-A and Apo-B, were measured before and after the training period. Data were analyzed using repeated measures of ANOVA. A p-value less than 0.05 was considered statistically significant. Results: Aerobic and resistance training significantly increased the expression of ABCG4 gene, compared to those in the control group (P=0.001); nonetheless, there was no significant difference between the two training groups (P= 0.021). Significant differences were observed in serum levels of Apo-A and Apo-B in both aerobic and resistance training groups, compared to those obtained in the control group (P=0.001). However, the difference between aerobic and resistance training groups was significant for Apo-A (P= 0.001), but not for Apo-B (P=1.000). Moreover, the ratio of Apo-A to Apo-B was significantly different for the resistance training group, compared to that in the control group (P= 0.001); nevertheless, it was not significant for the aerobic training group (P=1.000). Conclusion: As evidenced by the results of this study, resistance training improves cholesterol reverse transport regulators more than aerobic training; therefore, resistance training is recommended to regulate reverse cholesterol transfer. Keywords: Aerobic training, Resistance training, reverse cholesterol transfer, ATP-binding cassette transporters.

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