The effect of different concentrations of cerium oxide ‎during pregnancy on ovarian follicle development in ‎neonatal mice

Nemati, Afsaneh and Beyranvand, Fatemeh and Assadollahi, Vahideh and Salahshoor, Mohammad Reza (2020) The effect of different concentrations of cerium oxide ‎during pregnancy on ovarian follicle development in ‎neonatal mice. Birth Defects Research.

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Abstract

Objectives Cerium is a member of the rare metals group and widely used in drug delivery, gene therapy, ‎molecular imaging and medicine. In this study, we investigated the effect of different doses of ‎Cerium (IV) oxide (CeO2) during pregnancy on neonatal mice ovaries, as well as its effect on ‎blood biochemical parameters.‎ Methods Thirty pregnant NMRI mice were divided into five groups: Control and 4 groups treated with ‎CeO2 (10, 25, 80, 250 mg/kg.bw i.p) at the GD7 and GD14. The ovarian histological of neonatal ‎‎(2 and 6 day‐olds), as well as blood serum of neonates at 15‐dpp were analyzed.‎ Results Count of ovarian primordial follicles in neonates at 2 dpp showed a significant decrease in the ‎groups treated with 80 and 250 mg/kg.bw doses of CeO2. There was also a significant decrease in ‎ovarian primordial and primary follicles in neonates at 6‐dpp at 250 mg/kg.bw doses of CeO2 in ‎the control (P < 0.05). There was no significant difference in serum levels of malondialdehyde ‎and total antioxidant capacity between the experimental and control groups.‎ Conclusions Our results suggest that the effects of CeO2 on the ovarian tissue of neonatal mice during ‎pregnancy may be dose‐dependent.‎

Item Type: Article
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: lorestan university
Date Deposited: 16 Dec 2020 07:00
Last Modified: 16 Dec 2020 07:00
URI: http://eprints.lums.ac.ir/id/eprint/2472

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