The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats

Moghaddasi, Mehrnoush and Taati, Majid and Asadian, Payman and Khalatbary, Ali Reza and Asaei, Raheleh and Pajouhi, Naser (2017) The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats. JOURNAL OF PHYSIOLOGICAL SCIENCES, 67. pp. 415-423. ISSN 1880-6546

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Abstract

The purpose of this study was to evaluate the effects of cerebral hypoperfusion on cognitive ability, TNF alpha, IL1 beta and PGE2 levels in both hippocampi in a modified two-vessel occlusion model. Both common carotid arteries of adult male Wistar rats were permanently occluded with an interval of 1 week between occlusions. Learning and memory were significantly decreased after 1 month. This reduction was not significant after 2 months, which may be attributed to blood flow compensation. The TNF alpha level was significantly increased after 3 h and 1 day. IL1 beta was significantly increased after 1 day. After a week there was no significant difference in pro-inflammatory levels. Furthermore, there was no difference between right and left hippocampi. It is possible that TNF alpha and IL1 beta elevation initiates pathologic processes that contribute to memory impairment. Keywords Author Keywords:Cerebral hypoperfusion; Inflammation; Interleukins; Spatial memory; Hippocampus

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