VDR Gene Polymorphisms in Susceptibility to Pulmonary Tuberculosis among the LUR Population of Lorestan Province of Iran

Shahsavar, Farhad and Amiri, Ali and Sabooteh, Tooma and Hadilou, Mehrad and Azargoon, Alireza (2017) VDR Gene Polymorphisms in Susceptibility to Pulmonary Tuberculosis among the LUR Population of Lorestan Province of Iran. INTERNATIONAL JOURNAL OF ADVANCED BIOTECHNOLOGY AND RESEARCH, 8. pp. 2140-2148. ISSN 0976-2612

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Abstract

The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages has been associated to tuberculosis risk. The aim of this study was to determine whether vitamin D receptor (VDR) FokI, TaqI, BsmI, and ApaI polymorphisms are associated with the susceptibility to pulmonary tuberculosis (TB) in the Lur population of Iran. This case-control study included 100 patients with pulmonary tuberculosis age and sex matched and 100 healthy controls in a Lur population living in Lorestan province. Polymorphisms of VDR were analyzed by using polymerase chain reaction-restriction fragment length (PCR-RFLP) technique. Association analyses were performed with the SPSS 21 statistical software. The distribution of BsmI (Bb) genotype polymorphism were significantly higher frequency in TB patients compared to controls (61% vs. 45%, P=0.0336, OR=1.912, % 95 CI=1.089-3.356). However, the allelic and genotypic frequencies of FokI, TaqI and ApaI polymorphisms were not significantly different between the patients and the controls. Our findings demonstrated that BsmI (Bb) polymorphism may increase the susceptibility to pulmonary TB in the Lur population of Iran. We suggest that genotypes of many polymorphic genes are associated with TB, it is necessary to further more studies with larger sample size and explore the mechanism of genotypes in susceptibility to tuberculosis. Keywords Author Keywords:VDR; Pulmonary Tuberculosis; Lur population

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 02 Dec 2017 21:33
Last Modified: 02 Dec 2017 21:33
URI: http://eprints.lums.ac.ir/id/eprint/961

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