A review of the most important native medicinal plants of Iran effective on leishmaniasis according to Iranian ethnobotanical references

Naserifar, Razi and Bahmani, Mahmoud and Abdi, Jahangir and Abbaszadeh, Saber and Nourmohammadi, Gholam-Ali and Rafieian-Kopaei, Mahmoud (2017) A review of the most important native medicinal plants of Iran effective on leishmaniasis according to Iranian ethnobotanical references. INTERNATIONAL JOURNAL OF ADVANCED BIOTECHNOLOGY AND RESEARCH, 8. pp. 1330-1336. ISSN 0976-2612

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Abstract

The World Health Organization has declared that leishmaniasis is one of the six leading infectious diseases of tropical regions. The disease is transmitted to humans by the bite of sandflies from the genus Phlebotomus and develops cutaneous, mucosal or visceral clinical forms. Although cutaneous leishmaniasis is not a main health issue in terms of mortality, it causes numerous problems due to long period of the wound, tremendous healthcare costs, remaining scar, the likelihood of developing secondary infections or associated complications and sometimes malignancies in the scar site, and complications due to available pharmacotherapies. Studies are being conducted on medicinal plants to identify a suitable drug against Leishmania to treat leishmaniasis. We sought to identify medicinal plants that are used to treat cutaneous leishmaniasis according to references of Iranian traditional medicine. To conduct this review, Leishmania, leishmaniasis, ethnobotany, Iran, and medicinal plants were used to retrieve relevant publications indexed in databases including Scopus, Islamic World Science Citation Center, Scientific Information Database, and Magiran. According to the findings of this review, nine medicinal plants native to Iran are used to treat leishmaniasis. Medicinal plants Calotropis procera, Morus alba, Nerium oleander, Emex spinose, Artemisia absinthium, Artemisia absinthium, and etc are used to treat the wound according to herbal and traditional references. According to phytochemical analysis of these plants, gutaprecha, prenylated flavonoid, scopolin, reseosaid, skimmin, mulberroside A, astroglide, artemisinin, quercetin, and lawson are the most important active anti-leishmaniasis compounds with pharmaceutical potential as well as antiparasitic and disinfectant properties. These compounds can also be used to treat leishmaniasis wound. Keywords Author Keywords:Leishmania; leishmaniasis; medicinal plants; Iran

Item Type: Article
Subjects: R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 23 Oct 2017 12:13
Last Modified: 23 Oct 2017 12:13
URI: http://eprints.lums.ac.ir/id/eprint/917

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