Cardiovascular Toxicity of Cyclooxygenase Inhibitors and Promising Natural Substitutes

Bahmani, Mahmoud and Sarrafchi, Amir and Shirzad, Hedayatollah and Asgari, Sedigheh (2017) Cardiovascular Toxicity of Cyclooxygenase Inhibitors and Promising Natural Substitutes. CURRENT PHARMACEUTICAL DESIGN, 23. pp. 952-960. ISSN 1381-6128

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Abstract

Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs which are used for a wide variety of diseases including pain and inflammatory conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal disorders, and other comorbid complications. However, this group of drugs have undesirable effects such as peptic ulcer, bleeding and renal failure. Some of these side effects are associated with or caused by generation of oxidative stress. Following the withdrawal of a cyclo-oxygenase-2 (COX-2) inhibitor drug, rofecoxib (VIOXX (R)) due to cardiovascular complications, scientists suggested that natural COX-2 inhibitors might provide valuable alternatives to COX inhibitors. Although, most of medicinal plants reduce pain and inflammation in a similar manner to synthetic medications, however, they often have fewer side effects and are better tolerated. The present review other than focusing on cardiovascular and some other complications of NSAIDs, is trying to introduce the natural alternative remedies for these medications. Keywords Author Keywords:Cardiovascular; COX; NSAID; medicinal plants; oxidative stress; toxicity

Item Type: Article
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: sobhan rezaiian
Date Deposited: 23 Oct 2017 12:13
Last Modified: 23 Oct 2017 12:13
URI: http://eprints.lums.ac.ir/id/eprint/910

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