A comparision of intestinal biopsies and serologic anti-tissue transglutaminase in children with seliac disease in Ahvaz city in 2015

NiyaPak*, Somayeh and Ghadiri, Atalah and Ghaforiyan Broujerdniya, Mrehri and Hakimzadeh, Mehran (2106) A comparision of intestinal biopsies and serologic anti-tissue transglutaminase in children with seliac disease in Ahvaz city in 2015. yafte, 18 (2).

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Abstract

Background: CD or gluten-sensitive enteropathy is caused by dietary gluten ingestion in geneticallysusceptible individuals.The aim of the study was to compare the current diagnostic methods of CD and relationship between these methods. Material and Method: In this study 50 patients suspicious to have celiac disease were studied. After IgA anti-TTG test using Eliza method, the patients went under upper endoscopy, then histopathologic findings were grouped by Marsh classification. Results: Fifty patients, 23 males and 27 females with mean age of 8.36 were included in the study. TTG-IgA test was positive in 45 patients. Most pattients were categorized as Marsh stage III ( 28 cases) by histopathologic examination, which can be seen in other studies. We found significant correlation between histopathologic and serologic findings (p-valu=0.014). no significant correlation was found between histopathological test and patients age. Conclusion: Based on the results obtained in this study between histopathologic findings and serologic findings were significant relationship, The diagnostic approach presented in this study may also be useful in the assessment of CD. In the end, for a definitive diagnosis of celiac disease, molecular tests and also determination of haplotype HLADQ are recommended. Keywords: Celiac disease ,Anti-tissue Transglutaminase (TTG) , Marsh stage.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
Depositing User: Samira Sepahvandy
Date Deposited: 13 Sep 2016 06:01
Last Modified: 13 Sep 2016 06:01
URI: http://eprints.lums.ac.ir/id/eprint/86

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