Effect of alcoholic extract of olive leaves on Serum Level of FSH, LH and Testosterone fallowing renal ischemic- reperfusion injury in Male Rats

Nasirzadeh*, Mohamad Reza (2017) Effect of alcoholic extract of olive leaves on Serum Level of FSH, LH and Testosterone fallowing renal ischemic- reperfusion injury in Male Rats. Yafte, 19 (1).

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Abstract

Background : In males, testosterone reduction is one of the complications of renal ischemia. Olive leaf is a significant source of bioactive phenolic compounds. They have better antioxidant capacity, anti-inflammatory and radical scavenging. The purpose of this study was to investigate the effect of olive leaf extract (OLE) on serum level of Gonadotropins and testosterone. Materials and Methods: In this study forty – nine male rats were randomly divided into seven groups:1)control : which were intact animals 2)I/R 1h, 3)I/R1h+ OLE, 4)I/R 2h , 5)I/R 2h+ OLE),6) I/R 24h and 7) I/R24h+ OLE. The animals in 3,5and 7 groups received 100mg/kg olive leaf extract in 0.5 ml drinking water using gavages for 28 days. At the end of the treatment, levels of urea, Creatinin FSH, LH and testosterone were determined in serum. Results: The results showed that serum urea and Creatinin level in the control group was significantly lower than other groups (P>0.05).also, revealed that serum level of testosterone in I/R 24h group significantly decreased in comparison with I/R24h+olive leaf extract group(P>0.05). Conclusion: This study indicated that oral administration of olive leaf extract can prevent from testosterone reduce in I/R 24h group. Keywords: Renal ischemic- reperfusion, Gonadotropin, Testosterone, Olive leaf extract, Male rat.

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