SEMINAL PLASMA LEVELS OF FREE 8-ISOPROSTANE AND ITS RELATIONSHIP WITH SPERM QUALITY PARAMETERS

Khosrowbeygi, Ali and Zarghami, Nosratollah (2009) SEMINAL PLASMA LEVELS OF FREE 8-ISOPROSTANE AND ITS RELATIONSHIP WITH SPERM QUALITY PARAMETERS. SEMINAL PLASMA LEVELS OF FREE 8-ISOPROSTANE AND ITS RELATIONSHIP WITH SPERM QUALITY PARAMETERS, 5 (3). pp. 49-52. ISSN 6544-32532

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Abstract

There is growing evidence that damage to spermatozoa by reactive oxygen species play a key role in male infertility. The aim of this study was to assess seminal plasma free 8-Isoprostane levels in men with asthenozoospermia, asthenoteratozoospermia and oligoasthenoteratozoospermia compared to normozoospermic males and its correlation with seminal parameters. The case group consisted of men with asthenozoospermia (n=15), asthenoteratozoospermia (n=16) and oligoasthenoteratozoospermia (n=15). The control group consisted of 16 males with normozoospermia. After Purification of Free 8-Isoprostane by affinity column, its concentration was measured by enzyme immunoassay method. Free 8-Isoprostane evaluation showed significantly greater values in the total case group (n=46) versus control group (18.23±3.56 vs 2.6±0.38 ng/ml). In each case group free 8-Isoprostane also showed a significant increasing compared to normozoospermic males. Free 8-Isoprostane showed an inversely significant correlation with sperm motility and sperm morphology. Lipid peroxidation could have significant role in etiology of sperm abnormalities. Measurement of 8-Isoprostane can be used as a specific biomarker for assessing lipid peoxidation in sperm.

Item Type: Article
Subjects: G Geography. Anthropology. Recreation > G Geography (General)
G Geography. Anthropology. Recreation > GB Physical geography
Depositing User: sobhan rezaiian
Date Deposited: 23 Oct 2017 12:09
Last Modified: 23 Oct 2017 12:09
URI: http://eprints.lums.ac.ir/id/eprint/773

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