Baharvand, Babak and Esmaili Dehaj, Mansour and Bahram, Rasoulian and Namdari, Mehrdad and Shikhani, Yaghoob and Kiani, Ali Asghar (2009) Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: Involvement of CGRP, PKC and mKATP channels. Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: Involvement of CGRP, PKC and mKATP channels, 55 (5). pp. 185-192. ISSN 4564-5455
Full text not available from this repository.Abstract
this study in anesthetized rats were to determine whether NTG has a delayed anti-arrhythmic effect and if so, whether calcitonin generelated peptide (CGRP), protein kinase C (PKC) and mitochondrial KATP channels (mKATP) are involved in triggering this response. For this purpose, on day 0, male Wistar rats received NTG (120 μg/kg, iv) with or without pre-administration of PKC inhibitor chelerythrine (CHE), capsaicin (CAP) to deplete CGRP from sensory nerves or mKATP channel blocker 5-hydroxydecaonic acid (5HD). On day 1, their hearts were subjected to 30 min ischemia and 120 min reperfusion. In rats pretreated with NTG, the incidence of ventricular tachycardia and ventricular fibrillation and the mortality rate significantly reduced (from 100%, 61% and 18.1% in the control group to 45.4%, 10% and 0% in the NTG group, respectively). Infarct size also reduced from 58±4.7% in the control group to 31±3.7% in the NTG group. These effects were abolished by CHE, CAP and 5HD, which none of them alone had any effect on infarct size or the incidence of myocardial arrhythmias. These results show that a low dose of NTG has a delayed anti-arrhythmic effect and this effect may share a common mechanism with antiinfarct effects of this drug, involving CGRP release and PKC and mKATP activation. © 2008 Elsevier Ireland Ltd. All rights reserved
| Item Type: | Article |
|---|---|
| Subjects: | L Education > LA History of education |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 23 Oct 2017 12:09 |
| Last Modified: | 23 Oct 2017 12:09 |
| URI: | http://eprints.lums.ac.ir/id/eprint/772 |
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