Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis

(Sayehmiri, , Fatemeh and (Kiani,, Faezeh) and Sayehmiri,, , Kourosh) and (Soroush,, Setareh)[ and Asadollahi,, Khairollah and Alikhani,Alikhani,, Mohammad Yousef and (Delpisheh, Ali) and Emaneini,, Mohammad and L (Bogdanovic, , Lidija and Varzi,, Ali Mohammad) (2015) Prevalence of cagA and vacA among Helicobacter pylori-infected patients in Iran: a systematic review and meta-analysis. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 9 (7). pp. 686-676. ISSN 1972-2680

Full text not available from this repository.

Abstract

The varieties of infections caused by Helicobacter pylori may be due to differences in bacterial genotypes and virulence factors as well as environmental and host-related factors. This study aimed to investigate the prevalence of cagA and vacA genes among H. pylori-infected patients in Iran and analyze their relevance to the disease status between two clinical groups via a meta-analysis method. Different databases including PubMed, ISI, Scopus, SID, Magiran, Science Direct, and Medlib were investigated, and 23 relevant articles from the period between 2001 and 2012 were finally analyzed. The relevant data obtained from these papers were analyzed by a random-effects model. Data were analyzed using R software and STATA. The prevalence of cagA and vacA genes among H. pylori-infected patients was 70% (95% CI, 64-75) and 41% (95% CI, 24.3-57.7), respectively. The prevalence of duodenal ulcers, peptic ulcers, and gastritis among cagA+ individuals was 53% (95% CI, 20-86), 65% (95% CI, 34-97), and 71% (95% CI, 59-84), respectively. Odds ratio (OR) between cagA-positive compared with cagA-negative patients showed a 1.89 (95% CI, 1.38-2.57) risk of ulcers. In conclusion, the frequency of cagA gene among H. pylori strains is elevated in Iran and it seems to be more frequently associated with gastritis. Therefore, any information about cagA and vacA prevalence among different H. pylori-infected clinical groups in the country can help public health authorities to plan preventive policies to reduce the prevalence of diseases associated with H. pylori infection

Item Type: Article
Subjects: R Medicine > RB Pathology
Depositing User: sobhan rezaiian
Date Deposited: 23 Oct 2017 12:05
Last Modified: 23 Oct 2017 12:05
URI: http://eprints.lums.ac.ir/id/eprint/707

Actions (login required)

View Item View Item