A COMPARATIVE STUDY OF THERAPEUTIC EFFECTS OF DOXEPIN AND CETIRIZINE IN PATIENTS WITH ALLERGIC RHINITIS: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL

Aghajanpour, Mohammad and Zamani Barsari, Farzad and Saleh Jafari, Neda and Soheili, Habib and Jamilian, Hamid Reza and Rafiei, Mohammad and Tamizi, Amin (2016) A COMPARATIVE STUDY OF THERAPEUTIC EFFECTS OF DOXEPIN AND CETIRIZINE IN PATIENTS WITH ALLERGIC RHINITIS: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. The IIOAB Journal– Institute of Integrative Omics and Applied Biotechnology Journal, 7 (8). pp. 130-133.

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Abstract

ABSTRACT Allergic rhinitis is a common disease presenting in 20% of the population. Major symptoms are including sneezing, rhinorrhea, nasal congestion, and nasal pruritus. It is seemed that tricyclic antidepressants blocking histamine receptors might be applied as an effective treatment in allergic rhinitis. In the current clinical trial, a total of 84 subjects with allergic rhinitis were enrolled and randomly assigned to 2 groups. Both groups were administered cetirizine and doxepin for 2 weeks. The subjects were evaluated in terms of sneezing, rhinorrhea, nasal congestion, and nasal pruritus after 2 weeks of taking the aforementioned medications. There was no difference in the clinical score of the patients after 2 weeks (p = 0.261). Sneezing was the only symptom that was affected by the type of remedy, it was significantly different between the groups (p = 0.005). The findings of the present study indicated that there is no substantial difference in taking cetirizine and doxepin in treating seasonal allergic rhinitis symptoms. Administering TCAs with more potency of blocking histamine receptors and larger population are necessary for future studies.

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