Assessment of Depression Prevalence and Its Relation With Interleukin 18 One Year After Renal Transplantation

Sahraei, Zahra and Mehdizadeh, Mona and Eslami,, Neda and Eshraghi, Azadeh (2015) Assessment of Depression Prevalence and Its Relation With Interleukin 18 One Year After Renal Transplantation. American Journal of Therapeutics.

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Abstract

Renal transplantation is the treatment of choice for many patients with end-stage renal disease. Because there is little information about depression after kidney transplantation, we investigated frequency and determinant factors of depression and also its association with interleukin (IL)-18. Kidney transplant recipients were investigated between January 2011 and February 2013. Depression was assessed using the Beck Depression Inventory (BDI, BDI-II). We investigated the relationship between 1-year posttransplantation depression and all-cause mortality, acute kidney injury, and serum creatinine 1, 3, and 12 months after transplantation. Furthermore, the association of depression with IL-18 biomarker was recorded 1 year after transplantation. A total of 74 patients (age: 37.06 6 16.2 years; 59.5% male) were enrolled in this study 1 year after transplantation. Nineteen (25.6%), 2 (2.7%), and 1 (1.3%) of them experienced mild, moderate, and severe depression, respectively. IL-18 biomarker (independent variable) was significantly associated with depression 1 year after transplantation. Our data suggested that IL-18 level increased significantly in renal transplant patients with depression. Keywords: depression, interleukin 18, renal transplantation

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