Circulating microRNA: a new candidate for diagnostic biomarker in neuroblastoma

Mohammadi, Mohsen and Goodarzi, M and Jaafari, MR and Mirzaei, HR and Mirzaei, H Circulating microRNA: a new candidate for diagnostic biomarker in neuroblastoma. Cancer Gene Therapy.

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Abstract

Neuroblastoma (NB) is known as a pediatric neoplasm that is associated with variable histopathological features. The use of biomarkers contributes to the monitoring and treatment of various malignancies such as NB. The identification of novel biomarkers such as (epi)genetic biomarkers and microRNAs (miRNAs) in NB has led to better treatments of NB. Among them, miRNAs have emerged as powerful tools in diagnosis, prognosis and therapeutic biomarkers for patients with NB. Circulating biomarkers such as circulating miRNAs present in body fluids (for example, plasma, serum and urine) provided an interesting field of study in NB treatment. The miRNAs have central roles in different pathogenic events in various malignancies such as NB. Hence, these molecules can be a suitable candidate for monitoring and treating NB patients. Here, we summarize some miRNAs as potential prognosis, diagnosis and therapeutic biomarkers in NB.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: sobhan rezaiian
Date Deposited: 06 May 2017 05:20
Last Modified: 06 May 2017 05:20
URI: http://eprints.lums.ac.ir/id/eprint/522

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