Colon cancer targeting using conjugates biomaterial 5-flurouracil

Jaferian, Soleiman and Negahdari, Babak and Eatemadi, Ali (2016) Colon cancer targeting using conjugates biomaterial 5-flurouracil. Biomedicine & Pharmacotherapy, 84. pp. 780-788.


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There has been several research works on the development of an oral delivery system to deliver cytotoxic and chemo preventive agents directly at the targeted site of action with reduced unwanted side effects. The efficacy of the site-specific delivery system of a drug to colon has been proven to increase the drugs concentration at the target site, and thus requires a reduced dose of the drug with minimized side effects. This review includes discussion of the delivery systems of 5-FU using biodegradable materials and some significant outcomes in the pre-clinical development of 5-fluorouracil carriers for the colon cancer. ã 2016 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: samira sepahvandy
Date Deposited: 06 May 2017 05:11
Last Modified: 10 Nov 2017 11:38

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