Beiranvand, Zohreh and Alamdary, Ashkan and Mohammadi, Rasool and Ajorloo, Mehdi (2025) Association Between the Vitamin D Receptor Polymorphism in rs7975232 with the COVID-19 Susceptibility. Genet Test Mol Biomarkers.
Full text not available from this repository.Abstract
Background: Vitamin D deficiency influences the pathogenicity and severity of coronavirus disease 2019 (COVID-19), suggesting that polymorphisms in the vitamin D receptor may impact disease susceptibility and outcomes. This study aims to examine the relationship between the rs7975232 SNP and susceptibility to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) infection. Materials and Methods: This study compared 138 COVID-19 patients with 136 healthy individuals at Shohada-ye Ashayer Hospital in Khorramabad. The PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) method was employed to ascertain the genotypes following the collection of blood samples. The results of PCR-RFLP method were confirmed by sequencing. IBM SPSS and SNPStats software were utilized to compare genotypes and allele frequencies, as well as to conduct odds ratio analysis. Results: This study's results did not demonstrate a significant association between the rs7975232 polymorphism and COVID-19 susceptibility (p = 0.58). Subsequent analysis revealed that individuals with low lymphocyte levels and the CC genotype exhibited increased susceptibility to COVID-19 (OR = 3.45, 95%CI: 1.18-10.11). A significant association was observed between creatinine (p < 0.0001), neutrophils (p = 0.02), and NLR (Neutrophil to Lymphocyte Ratio) (p = 0.0015) with rs7975232. In a comparison of AA/AC genotype cases, individuals with normal levels of ALT, CPK, creatinine, blood sugar, and hemoglobin exhibited an increased likelihood of infection. In CC genotype cases, individuals with normal neutrophil levels exhibited a reduced chance of COVID-19. Conclusion: The current study did not demonstrate a significant association between the examined SNP and COVID-19. The findings indicated that the standard levels of various laboratory parameters influence the likelihood of the disease. Additional studies involving larger and more diverse populations can yield more valid results
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 16 Aug 2025 04:49 |
| Last Modified: | 16 Aug 2025 04:49 |
| URI: | http://eprints.lums.ac.ir/id/eprint/5183 |
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