Mehdi Behvandi, Mohammad and Sabbagh, Susan and Rostami, Reza and Jafarian, Ashkan and Jafarian, Marjan (2025) Effect of gallic acid in mitigating hepatorenal injuries induced by gentamicin administration in male Wistar rats. Naunyn Schmiedebergs Arch Pharmacol.
Full text not available from this repository.Abstract
Gentamicin (GEN) causes liver and kidney toxicity by generating free radicals and inflammation. This study tested gallic acid (GA) as an antioxidant to reduce this oxidative stress. Thirty-five male rats were divided into five groups: sham, GEN, and three GEN + GA groups with doses of 60, 90, and 120 mg/kg. After 10 days, the rats were euthanized, and their serum, kidneys, and livers were analyzed. Results showed that GEN significantly increased serum BUN, creatinine, AST, ALT, and ALP (p < 0.05). It also raised malondialdehyde (MDA) levels and the expression of TNF-α and caspase-3 genes, with notable histopathological injuries in the kidneys and liver (p < 0.05). GA demonstrated potential protective effects against GEN-induced damage. GEN reduced antioxidant enzyme activities (GPX, CAT, and GSH) in the organs (p < 0.05). Conversely, GA at all doses lowered BUN, creatinine, ALT, AST, ALP, and MDA levels and decreased TNF-α and caspase-3 gene expression in the liver and kidneys (p < 0.05). It also protected against tissue injuries and boosted antioxidant enzyme levels in both organs (p < 0.05). The study shows that gallic acid (60, 90, 120 mg/kg) significantly mitigates gentamicin-induced hepatorenal toxicity by reducing oxidative stress, inflammation, and apoptosis. Notably, doses of 90 and 120 mg/kg were especially more effective in minimizing tissue damage and improving antioxidant activity
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 02 Jul 2025 03:27 |
| Last Modified: | 02 Jul 2025 03:27 |
| URI: | http://eprints.lums.ac.ir/id/eprint/5150 |
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