Kiani, Pouria and Khodadadi, Elaheh Sadat and Nikdasti, Ali and Yarahmadi, Sahar and Gheibi, Mobina and Yousefi, Zeynab and Ehtiati, Sajad and Yahyazadeh, Sheida and Shafiee, Sayed Mohammad and Taghizadeh, Motahareh and Igder, Somayeh and Khatami, Seyyed Hossein and Karima, Saeed and Vakili, Omid and Pourfarzam, Morteza (2025) Autophagy and the peroxisome proliferator-activated receptor signaling pathway: A molecular ballet in lipid metabolism and homeostasis. Molecular and cellular biochemistry.
Full text not available from this repository.Abstract
Lipids, which are indispensable for cellular architecture and energy storage, predominantly consist of triglycerides (TGs), phospholipids, cholesterol, and their derivatives. These hydrophobic entities are housed within dynamic lipid droplets (LDs), which expand and contract in response to nutrient availability. Historically perceived as a cellular waste disposal mechanism, autophagy has now been recognized as a crucial regulator of metabolism. Within this framework, lipophagy, the selective degradation of LDs, plays a fundamental role in maintaining lipid homeostasis. Dysregulated lipid metabolism and autophagy are frequently associated with metabolic disorders such as obesity and atherosclerosis. In this context, peroxisome proliferator-activated receptors (PPARs), particularly PPAR-γ, serve as intracellular lipid sensors and master regulators of gene expression. Their regulatory influence extends to both autophagy and lipid metabolism, indicating a complex interplay between these processes. This review explores the hypothesis that PPARs may directly modulate autophagy within the realm of lipid metabolism, thereby contributing to the pathogenesis of metabolic diseases. By elucidating the underlying molecular mechanisms, we aim to provide a comprehensive understanding of the intricate regulatory network that connects PPARs, autophagy, and lipid homeostasis. The crosstalk between PPARs and other signaling pathways underscores the complexity of their regulatory functions and the potential for therapeutic interventions targeting these pathways. The intricate relationships among PPARs, autophagy, and lipid metabolism represent a pivotal area of research with significant implications for understanding and treating metabolic disorders. Keywords: Autophagy; Lipid metabolism; Lipophagy; Peroxisome proliferator-activated receptors; Signal transduction.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 04 Feb 2025 09:19 |
| Last Modified: | 04 Feb 2025 09:19 |
| URI: | http://eprints.lums.ac.ir/id/eprint/5003 |
Actions (login required)
 |
View Item |
