Amin, Arash and Mohajerian, Ahmad and Rashki Ghalehnoo, Sara and Mohamadinia, Mehdi and Ahadi, Shana and Sohbatzadeh, Tooba and Pazoki, Mahboubeh and Afshin Hasanvand, Afshin and Faghihkhorasani, Ferdos and Habibi, Zeinab (2024) Potential Player of Platelet in the Pathogenesis of Cardiotoxicity: Molecular Insight and Future Perspective. Cardiovascular toxicology.
Full text not available from this repository.Abstract
Cancer patients may encounter the onset of cardiovascular disease due to tumor advancement or chemotherapy, commonly known as "cardiotoxicity." In this respect, the conventional chemotherapy treatment protocol involves a mixture of different medications. These medications can be detrimental to cardiac tissue, consequently exposing the patient to the possibility of irreversible cardiac injury. The enhancement of oxidative stress and inflammation is an important mechanism of chemotherapeutic agents for developing cardiotoxicity. Regarding their dual pro- and anti-inflammatory functions, platelets can significantly influence the progression or suppression of cardiotoxicity. Therefore, the expression of platelet activatory markers can serve as valuable prognostic indicators for cardiotoxicity. The primary objective of this study is to examine the significance of platelets in cardiotoxicity and explore potential strategies that could effectively target malignant cells while minimizing their cytotoxic impact, such as cardiotoxicity and thrombosis. Keywords: Cardiotoxicity; Nano-particle; Pathogenesis; Platelet; Thrombosis.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | lorestan university |
| Date Deposited: | 26 Oct 2024 10:43 |
| Last Modified: | 26 Oct 2024 10:43 |
| URI: | http://eprints.lums.ac.ir/id/eprint/4928 |
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