Alizadeh, Seyed Danial and Jalalifar, Mohammad-Rasoul and Ghodsi, Zahra and Sadeghi-Naini, Mohsen and Malekzadeh, Hamid and Rahimi, Golnoosh and Mojtabavi, Kurosh and Shool, Sina and Eskandari, Zahra and Masoomi, Rasoul and Kiani, Sahar and Harrop, James and Rahimi-Movaghar, Vafa (2024) Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review. International Medical Society of Paraplegia.
Full text not available from this repository.Abstract
Study design A Systematic Review Objectives To determine the therapeutic efficacy of in vivo reprogramming of astrocytes into neuronal-like cells in animal models of spinal cord injury (SCI). Methods PRISMA 2020 guidelines were utilized, and search engines Medline, Web of Science, Scopus, and Embase until June 2023 were used. Studies that examined the effects of converting astrocytes into neuron-like cells with any vector in all animal models were included, while conversion from other cells except for spinal astrocytes, chemical mechanisms to provide SCI models, brain injury population, and conversion without in-vivo experience were excluded. The risk of bias was calculated independently. Results 5302 manuscripts were initially identified and after eligibility assessment, 43 studies were included for full-text analysis. After final analysis, 13 manuscripts were included. All were graded as high-quality assessments. The transduction factors Sox2, Oct4, Klf4, fibroblast growth factor 4 (Fgf4) antibody, neurogenic differentiation 1 (Neurod1), zinc finger protein 521 (Zfp521), ginsenoside Rg1, and small molecules (LDN193189, CHIR99021, and DAPT) could effectively reprogramme astrocytes into neuron-like cells. The process was enhanced by p21-p53, or Notch signaling knockout, valproic acid, or chondroitin sulfate proteoglycan inhibitors. The type of mature neurons was both excitatory and inhibitory. Conclusion Astrocyte reprogramming to neuronal-like cells in an animal model after SCI appears promising. The molecular and functional improvements after astrocyte reprogramming were demonstrated in vivo, and further investigation is required in this field.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 08 May 2024 07:29 |
| Last Modified: | 08 May 2024 07:29 |
| URI: | http://eprints.lums.ac.ir/id/eprint/4733 |
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