The Effect of the Hydroalcoholic Extract of Quercus infectoria Fruit Hulls (Jaft-E-Baloot) on Formalin-Induced Inflammation and Pain in Male Mice

Karimian, Ali and Nafari, Amirhossein and Sarvestani, Amirmehdi and Zamani, Amir and Behnaminia, Nima and Mohammadi, Rasool and Almasian, Mohammad and Kiani*, Ali Asghar (2024) The Effect of the Hydroalcoholic Extract of Quercus infectoria Fruit Hulls (Jaft-E-Baloot) on Formalin-Induced Inflammation and Pain in Male Mice. Herbal Medicines Journal.

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Abstract

Background and Aim: Herbal medicines have been used to alleviate inflammation and pain since ancient times, and their use is even on the rise. The Quercus infectoria plant has been commonly used for many years to treat inflammation and pain in alternative medicine. Various species and different parts of this plant have been studied. The present study aimed to investigate the anti-inflammatory and analgesic properties of the extract of the fruit hulls of Q. infectoria to find a plant-based alternative to the available drugs with fewer side effects. Materials and Methods: This study used 60 male NMRI mice with a weight range of 35-40 g. The mice were randomized into a negative control group which only received formalin, a positive control group that received diclofenac 200 µg/kg, and four experimental groups that received 50, 100, 150, and 200 mg/kg of the fruit hulls extraction. Formalin was injected into the paws of the mice to induce inflammation and pain. Then, the paw volume was measured during the first three hours after injection with a digital Plethysmometer. Pain score was also evaluated in three stages at 60-minute intervals. Results: The results showed that the fruit hulls extract could reduce inflammation at all doses, particularly at 200 mg/kg in comparison with the negative control group (p < 0.001). Moreover, the fruit hulls extract relieved pain at different doses in acute and chronic stages. Conclusion: The fruit hulls extract alleviated the pain and reduced the inflammation in mices' paws depending on the dose. Therefore, it can be considered as a possible alternative to chemical drugs.

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