Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite

Moghadam Fard, Atousa and Goodarzi, Pardis and Mottahedi, Mehran and Garousi, Setareh and Zadabhari, Hamed and Kalantari Shahijan, Mohammad and Esmaeili, Saeedeh and Nabi-Afjadi, Mohsen and Yousefi, Bahman (2024) Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite. Naunyn-Schmiedeberg's archives of pharmacology.

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Most animals have large amounts of the special substance melatonin, which is controlled by the light/dark cycle in the suprachiasmatic nucleus. According to what is now understood, the gastrointestinal tract (GIT) and other areas of the body are sites of melatonin production. According to recent studies, the GIT and adjacent organs depend critically on a massive amount of melatonin. Not unexpectedly, melatonin's many biological properties, such as its antioxidant, anti-inflammatory, pro-apoptotic, anti-proliferative, anti-metastasis, and antiangiogenic properties, have drawn the attention of researchers more and more. Because melatonin is an antioxidant, it produces a lot of secretions in the GIT's mucus and saliva, which shields cells from damage and promotes the development of certain GIT-related disorders. Melatonin's ability to alter cellular behavior in the GIT and other associated organs, such as the liver and pancreas, is another way that it functions. This behavior alters the secretory and metabolic activities of these cells. In this review, we attempted to shed fresh light on the many roles that melatonin plays in the various regions of the gastrointestinal tract by focusing on its activities for the first time. Keywords: Antioxidant; Gastrointestinal tract; IBD; Melatonin.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 26 Feb 2024 10:32
Last Modified: 26 Feb 2024 10:32

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