Zamani, Mohammad and Sohrab, Zahra and Aghakhani,, Ladan and Leilami, Kimia and Nosratabadi, Saeed and Namkhah, Zahra and Clark, Cain and Haghighat, Neda and Asbaghi,, Omid and Fathi, Fatemeh (2024) The effects of vitamin D and omega-3 co-supplementation on lipid profile in adults: a systematic review and meta-analysis. Nutrition and Food Science.
Full text not available from this repository.Abstract
Purpose Previous research indicates that vitamin D and omega-3 co-supplementation may benefit overall health, but current evidence regarding its effects on lipid profile remains unclear. The present systematic review and meta-analysis aimed to examine the effects of vitamin D and omega-3 co-supplementation on lipid profile (total cholesterol [TC], low-density lipoprotein [LDL], triglyceride [TG] and high-density lipoprotein [HDL]) in adults. Design/methodology/approach In this systematic review and meta-analysis, relevant studies were obtained by searching the PubMed, Scopus and Web of Science databases (from inception to January 2022). Weighted mean differences and 95% confidence intervals were estimated via a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods. Findings Pooled analysis of six randomized controlled trials (RCTs) revealed that vitamin D and omega-3 co-supplementation yielded significant reductions in TG ( p = 0.631). A pooled analysis of five trials indicated a significant association between omega-3 and vitamin D treatment and reductions in TC ( p = 0.001) and LDL ( p = 0.001). Although, pooled analyses of omega-3 and vitamin D did not significantly affect HDL. Originality/value The findings suggest that vitamin D and omega-3 co-supplementation lowers TG, TC and LDL in adults. Future, large-scale, RCTs on various populations are needed to elucidate further beneficial effects of vitamin D and omega-3 co-supplementation on lipid profile and establish guidelines for clinical practice.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 24 Feb 2024 07:26 |
| Last Modified: | 24 Feb 2024 07:26 |
| URI: | http://eprints.lums.ac.ir/id/eprint/4688 |
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