The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats

Mehrnoush Moghaddasi Jahromi, Lorestan University of Medical Sciences and Raheleh Asaei, Lorestan University of Medical Sciences and Naser Pajouhi, Lorestan University of Medical Sciences and Majid Taati, Faculty of Veterinary Medicine, Lorestan University and Payman Asadian, University of Guelph, Guelph and Ali Reza Khalatbary, Mazandaran University of Medical Sciences (2016) The effects of two-stage carotid occlusion on spatial memory and pro-inflammatory markers in the hippocampus of rats. J Physiol Sci.

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Abstract

Abstract The purpose of this study was to evaluate the effects of cerebral hypoperfusion on cognitive ability, TNFa, IL1b and PGE2 levels in both hippocampi in a modified two-vessel occlusion model. Both common carotid arteries of adult male Wistar rats were permanently occluded with an interval of 1 week between occlusions. Learning and memory were significantly decreased after 1 month. This reduction was not significant after 2 months, which may be attributed to blood flow compensation. The TNFa level was significantly increased after 3 h and 1 day. IL1b was significantly increased after 1 day. After a week there was no significant difference in pro-inflammatory levels. Furthermore, there was no difference between right and left hippocampi. It is possible that TNFa and IL1b elevation initiates pathologic processes that contribute to memory impairment. Keywords Cerebral hypoperfusion � Inflammation � Interleukins � Spatial memory � Hippocampus

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: sobhan rezaiian
Date Deposited: 13 Mar 2017 06:47
Last Modified: 13 Mar 2017 06:47
URI: http://eprints.lums.ac.ir/id/eprint/463

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