Mesenchymal stem cell: a new horizon in cancer gene therapy

M Mohammadi, Lorestan University of Medical Sciences and MR Jaafari, Mashhad University of Medical Sciences and HR Mirzaei, Tehran University of Medical Sciences and H Mirzaei, Mashhad University of Medical Sciences (2016) Mesenchymal stem cell: a new horizon in cancer gene therapy. Cancer Gene Therapy. ISSN 0929-1903

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Abstract

Cancer is one of the main problems in public health worldwide. Despite rapid advances in the diagnosis and treatment of cancer, the efficacy of current treatment strategies is still limited. There are promising new results in animal models whereby mesenchymal stem cells (MSCs) can be used as vehicles for targeted therapies. The use of MSCs as therapeutic biological vehicles in cell therapy has several advantages, including immune-silence, tumor tropism, easy and rapid isolation, ex vivo expansion, multilineage differentiation and the capacity to deliver a number of therapeutic agents. Some studies have shown that the microenvironment of the tumor provides a preferential niche for homing and survival of MSCs. Here, we have highlighted various applications of MSCs in cancer gene therapy.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: sobhan rezaiian
Date Deposited: 12 Mar 2017 08:02
Last Modified: 12 Mar 2017 08:02
URI: http://eprints.lums.ac.ir/id/eprint/449

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