Association Between Demographic Characteristics and Sperm DNA Fragmentation Index in Infertile Men

Khosravi, Parisa and Karimi Rouzbahani, Arian and Yousefi Yeganeh, Behzad and Sabzian, Maryam and Mahmoudvand, Golnaz and Yari, Fatemeh (2023) Association Between Demographic Characteristics and Sperm DNA Fragmentation Index in Infertile Men. Nephro-Urology Monthly.

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Abstract

Background: The DNA fragmentation index (DFI) is an essential marker in evaluating male fertility. Lifestyle is supposed to have a remarkable effect on enhancing this index and, subsequently, male fertility. Objectives: This study investigated the relationship between lifestyle habits and sperm DFI in infertile men admitted to Shahid Rahimi and Shohada-ye Ashayer hospitals in Khorramabad, Iran, from 2020 to 2021. Methods: This cross-sectional descriptive study was performed on 222 infertile men. The samples were divided into three groups based on their sperm DFI: < 15%, 15 - 30%, and < 30%. In each group, alcohol consumption, smoking, age, and body mass index (BMI) were compared. The analysis was performed by SPSS software (version 22) using the chi-square test and one-way analysis of variance (ANOVA) test. Results: The mean age of patients was 37.45 ± 5.99 years. The DFI was < 15%, 15 - 30%, and 30% < in 119 (53.6%), 69 (31.1%), and 34 (15.3%) individuals, respectively. The mean age in the DFI groups of less than 15%, 15 - 30%, and more than 30% was 35.88, 38.17, and 41.52 years, respectively. The analysis showed a significant difference in the mean age of the three groups (P < 0.05). However, there was no significant relationship between smoking, alcohol consumption, and BMI with DFI (P > 0.05). Conclusions: There was no significant relationship between lifestyle factors and DFI. However, large-scale studies are required to evaluate the role of these factors, as if their role in infertility is proven, lifestyle modification might be a potential method for managing infertility

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