Dual role of microRNAs in cancer metastasis

Alaee, Mahdi and Kiyamehr, Pegah and Maroufi, Faezeh and Maali, Amirhosein and Azad, Mehdi (2023) Dual role of microRNAs in cancer metastasis. Human Gene.

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Metastasis is one of the complex processes in cancer that can create by inappropriate interactions between tumor cells and their microenvironment. Tumor cells can migrate toward distant tissues and cause the spread of cancer by expressing and secreting different factors. Thus, prevention and early diagnosis of metastasis need a deep understanding of the mechanisms and factors that cancer cells apply to cancer progression. miRNAs are nucleotide fragments with a length of 19-25 bp that can bind to the 3′ untranslated region of mRNAs and dysregulate the gene expression; it interferes with various cellular processes. So, miRNAs can be considered oncogene or tumor-suppressor factors, which depend on miRNA targets and start a metastasis process and cancer development. In this review article, we investigate some recent studies about miRNAs and their role in tumorigenesis and metastasis; we also reviewed some miRNAs as therapeutic targets in cancers.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Depositing User: samira sepahvandy
Date Deposited: 25 Sep 2023 09:21
Last Modified: 25 Sep 2023 09:22
URI: http://eprints.lums.ac.ir/id/eprint/4435

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