Seroprevalence of Hepatitis E Virus in Iran: A Systematic Review and Meta-analysis

Meysam Behzadifar, Lorestan University of Medical Sciences and Shadi Abdi, Lorestan University of Medical Sciences and Kamran B Lankarani, Shiraz University of Medical Sciences and Masood Taheri Mirghaed, Iran University of Medical Sciences and Gholam Beyranvand, Lorestan University of Medical Sciences and Abouzar Keshavarzi, Shahid Sadoughi University of Medical Sciences, Yazd and Gholamreza Ghoreishinia, Zahedan University of Medical Sciences and Aziz Rezapour, Iran University of Medical Sciences and Masoud Behzadifar, Iran University of Medical Sciences (2016) Seroprevalence of Hepatitis E Virus in Iran: A Systematic Review and Meta-analysis. Middle East Journal of Digestive Diseases.

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Abstract

BACKGROUND Hepatitis E virus (HEV) is one of common causes of viral hepatitis worldwide with higher prevalence in tropical and subtropical regions. Although epidemics of HEV have been reported from Iran, there are variable reports of this infection out of epidemics from different parts of Iran. This study aimed to determine the seroprevalence of HEV in Iran. METHODS In this systematic review and meta-analysis we searched PubMed, Scopus, Science direct, Google Scholar, Scientific Information Databank (SID), IranMedex, and Magiran for all relevant studies published in either English or Persian languages, up to 2015. Pooled seroprevalence estimates with a DerSimonian-Laird random-effects model were calculated. Statistical heterogeneity among the included studies was evaluated by Cochrane Q statistic and I2. RESULTS 38 studies fulfilled the inclusion criteria compromising 18461 participants. The pooled seroprevalence rate of HEV in Iran was estimated about 10% (95% CI=0.09- 0.12) with maximum and minimum of 46% (95 % CI=0.42-0.50), and 0.01% (95 % CI=0.000-0.002), respectively. CONCLUSION HEV is common in Iran although the prevalence is lower than some neighbor countries. Keywords Hepatitis E Virus; Seroprevalence; Meta-analysis; Systematic review; Iran

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: lorestan university
Date Deposited: 12 Mar 2017 06:40
Last Modified: 12 Mar 2017 06:40
URI: http://eprints.lums.ac.ir/id/eprint/441

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