Yektay, Sina and Alamdary, Ashkan and Khanizadeh, Sayyad and Mohammadi, Rasool and Talei, Gholamreza and Ajorloo, Mehdi (2023) Association between the interleukin – 6 (IL-6) polymorphism in −174 G/C genotype (rs1800795) with the Covid-19 pathogenicity. Human Gene.
Full text not available from this repository.Abstract
Background In severe cases of COVID-19 with increased levels of inflammatory cytokines such as IL-6, a cytokine storm occurs, which can lead to respiratory failure. Due to the role of the IL-6 gene in respiratory diseases, and the fact that polymorphism of this gene may be one of the factors involved in disease severity, this study aimed to investigate the association of polymorphism-174G > C (rs1800795) of the IL-6 gene with COVID-19. Methods 200 individuals were studied in two groups of SARS-COV-2 positive and negative. The PCR-RFLP technique was applied to detect the polymorphism. The PCR products were digested using the NlaIII restriction enzyme. Results There was no association between rs1800795 and COVID-19 disease and disease severity. Among cases with pulmonary complications and cases with high CRP, GG genotype had a significantly higher chance for being infected. Among GG and GC genotypes, the age group of 36–50 had a significantly higher chance of infection. A lower chance of infection was also observed among cases with normal levels of ESR with GG and GC genotypes. Finally, considering cases with the GG genotype, the normal AST level was significantly associated with the disease. Among the age group of 36–50 the GC and CC genotypes were associated with severity. GC genotype had a lower and higher chance of disease severity in cases with high levels of ESR and AST, respectively. Conclusion In the present study, IL-6 polymorphism in the promoter region of 174 G > C (rs1800795) was not significantly associated with COVID-19 and the disease severity. Considering the result of this study, further analyses are suggested to ensure the association of ESR, AST, and CRP and the rs1800795 polymorphism with COVID-19 and the disease severity.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 13 Aug 2023 08:25 |
| Last Modified: | 13 Aug 2023 08:25 |
| URI: | http://eprints.lums.ac.ir/id/eprint/4364 |
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