Kazeminava, Fahimeh and Javanbakht, Siamak and Zabihi,, Mojtaba and Ahmadian, Zainab (2023) Crosslinking Chitosan with Silver-Sulfur Doped Graphene Quantum Dots: An Efficient Antibacterial Nanocomposite Hydrogel Films. Journal of Polymers and the Environment.
Full text not available from this repository.Abstract
Polysaccharides are among the most potent materials for wound dressing construction. In this study, antibacterial flexible hydrogel films were prepared through a novel crosslinking of biopolymeric chitosan (CS) with silver-sulfur doped graphene quantum dots (Ag@S-GQD). To end this, S-GQDs were first synthesized from citric acid and 3-mercaptopropionic acid via a direct pyrolysis method at 200 °C. Then, S-GQDs were used as a reducing agent for in-situ forming Ag nanoparticles toward the synthesizing Ag@S-GQD nanoparticles. They were incorporated within the biopolymeric CS matrix in different concentrations and hydrogel films were constructed via a simple casting method. Different techniques were considered to characterize and confirm the structure and properties of the constructed films. The results of the in-vitro cytotoxicity and antibacterial studies showed that the prepared nanocomposite, CS/Ag@S-GQD, has a good cytocompatibility toward Human skin fibroblast (HFF-1) cells (cell viability remained over ~ 90% even after 48 h of incubation) and considerable antibacterial activity against various gram-negative and positive bacterial strains (from 0.2 ± 0.1 to 0.8 ± 0.1 cm inhibition zone). The obtained results recommended this nanocomposite as a potential wound dressing.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RZ Other systems of medicine |
| Divisions: | Faculty of Medicine, Health and Life Sciences > School of Medicine |
| Depositing User: | samira sepahvandy |
| Date Deposited: | 08 Aug 2023 07:43 |
| Last Modified: | 08 Aug 2023 07:43 |
| URI: | http://eprints.lums.ac.ir/id/eprint/4354 |
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