Development of Tissue Engineering Scaffolds for Cancer Cell Cultures

Valizadeh Otaghsara, Seyede Maryam and Dariushnejad, Hassan and Mellati, Amir and Hasanzadeh, Elham and Abas, Mozhgan (2023) Development of Tissue Engineering Scaffolds for Cancer Cell Cultures. Journal of Mazandaran University of Medical Sciences.


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The cell culture technique is one of the tools used in cellular and molecular biology such as cancer cell culture, regenerative medicine, and drug discovery. In recent years, three-dimensional (3D) cell culture has gained attention in cancer research. Scaffolds are porous structures that are used in 3D cell culture to mimic the 3D architecture of tissues and provide more accurate information about tumor cells, extracellular matrix (ECM), and tumor characteristics. These scaffolds are based on synthetic polymers or ECM components and can promote the signaling pathways, survival, and proliferation of cancer cells. Natural and synthetic polymers, hydrogels and microspheres can be used to make 3D scaffolds. 3D cancer cell culture technology can improve cancer treatment. This review article discusses recent advances in the field of scaffold-based 3D models in cancer tissues.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine, Health and Life Sciences > School of Medicine
Depositing User: samira sepahvandy
Date Deposited: 06 Aug 2023 08:03
Last Modified: 06 Aug 2023 08:03

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